Protandim® Nrf2 Synergizer® activates your body’s own powerful antioxidant defenses to help you stay healthy every day. This patented herbal supplement is proven to reduce oxidative stress by 40% in 30 days.*

Your life demands you to be your healthy best every day. In order to live well, you need to be well. But there’s a lot working against you. The pressure to perform, fast foods, pollution, poor sleep, and not enough exercise—all of it can accumulate and leave you feeling … less than your best. Less energetic, less focused, and less vibrant.

What causes this feeling of less? Oxidative stress.

Oxidative stress can damage your body and your health at the cellular level. Fortunately, you can fight back. Your body has powerful built-in defenses. However, as early as in your 20s, these defenses can start to slow down. You can activate them with Protandim® Nrf2 Synergizer®.*

Protandim Nrf2 Synergizer is a patented blend of 5 herbal ingredients scientifically shown to reduce oxidative stress by 40% in 30 days. It works by targeting the Nrf2 genetic pathway in your body to trigger the release of antioxidants from the cell. Those antioxidants are your wellness defenders against the daily stresses and damage that can leave you feeling less than yourself.*

You can live well and age well. Get activated with Protandim Nrf2 Synergizer today.*

Learn more about the science and history behind Protandim Nrf2 Synergizer:
Discover the Science Behind Protandim

What is oxidative stress?

Scientists have many theories about what causes aging. One of the most well-researched is the Oxidative Stress Theory of Aging. Here’s a metaphor to help explain it.

Oxidative stress is like the accumulation of rust on a car. Through years of wear and tear, rust slowly begins to show as water and oxygen interact with the car’s surface. First a little rust here, then a little there. Eventually, rust begins to overtake everything.

Your cells act in a similar way. As you age, you begin to accumulate free radicals and other oxidants. Free radicals are highly reactive molecules that can damage cells and other tissues. It’s the rust inside your body.

Free radicals can come from the outside—sources like pollution and certain foods—and from the inside. Your natural detoxification and cellular energy production processes create a lot of free radicals. The very act of breathing introduces free radicals into your body, too.

Your body normally maintains a healthy balance of antioxidants to neutralize free radicals. The key is to maintain that balance. If there are too many free radicals or if your body is no longer producing as many antioxidants, it can lead to oxidative stress and damage that may impact cell health and function.

Watch this video to learn more about the Oxidative Stress Theory of Aging.
Oxidative Stress Theory of Aging – Protandim NRF2

Get the full science-speak on oxidative stress and Protandim Nrf2 Synergizer in this transcript of a podcast featuring LifeVantage Senior Vice President of R&D Brian Dixon.
Flip the “Antioxidant Switch”: Turn the Antioxidant Factory On in Your Body

How does Protandim® Nrf2 Synergizer® work?

Amazingly, your body has the ability to fight oxidants and free radicals. It’s encoded directly into your DNA and genes. These antioxidant and detoxification enzymes, however, need to be turned on to do their job. One of the proteins responsible for flipping that switch is called Nrf2. And Nrf2 can be activated using the power of nutrigenomics—using nutrients to influence your genes.*

Nrf2 is usually passive. It waits for a message that it needs to be released to defend against stresses. The nutrients from Protandim Nrf2 Synergizer send that message. Nrf2 gets released, travels into the nucleus, and activates your protective and survival genes. This triggers the release of your body’s antioxidants, including superoxide dismutase (SOD) and catalase.*

These antioxidants are significantly more powerful than dietary antioxidants like vitamin C, which can only neutralize a limited number of free radicals. Antioxidants like SOD can neutralize hundreds of free radicals and provide much better protection for your cells.*
High-Dose Antioxidant Supplements: Friend or Foe?

What’s in Protandim® Nrf2 Synergizer®?

A compound from broccoli called sulforaphane is an activator of Nrf2. You should still eat your broccoli, but Protandim Nrf2 Synergizer provides essentially the same cellular protection you’d get by eating 7 pounds of broccoli sprouts in one little yellow tablet. How? Synergy.*

Nature works together beautifully. When certain plant compounds are put together in specific ratios, they can enhance the benefits. The precise formula of Protandim Nrf2 Synergizer combines 5 phytonutrients in a patented blend.*
Behind the Scenes: The Powerful Ingredients in Protandim® Nrf2 Synergizer™

  • Turmeric: Turmeric root is the spice that gives curry its yellow color. It has been used in India for thousands of years as both a spice and medicinal herb. It modulates many molecular functions, helps support the body’s natural detoxification processes, and supports brain health, circulation, gut health, and more.*
    The All-Powerful, All-Purpose Turmeric Root
  • Green tea: Green tea includes large amounts of a catechin called epigallocatechin gallate (EGCG). These phytonutrients support healthy cell function, brain, mood, and metabolic health. Green tea can also help maintain healthy blood sugar levels, already within a normal range*
    The Bioactive Benefits of Green Tea
  • Bacopa (waterhyssop): Bacopa monnieri is a staple of traditional Ayurveda and has been used for centuries for a variety of purposes, including support for memory and learning rate and reducing everyday stress.*
    The Benefits of Bacopa
  • Ashwagandha: Ashwagandha is another important herb in Ayurveda. It’s long been used to reduce stress, aid healthy sleep, support concentration and overall brain function, and maintain healthy cholesterol levels, already within a normal range.*
    The Amazing Adaptogen: Ashwagandha
  • Milk thistle: Milk thistle is a flowering herb that supplies a compound called silymarin. Traditionally, it’s been used to help maintain liver, digestive, and cognitive health.*
    Get to Know Milk Thistle

This chart shows the results of a study that measured these 5 ingredients, both individually and combined (in Protandim Nrf2 Synergizer), and their ability to activate the Nrf2 pathway.*

IngredientMeasured Effect
Milk thistle extract1.5
Bacopa Monnieri extract1.3
Ashwagandha extract8
Turmeric extract2
Green tea extract2
ProductMeasured Effect
Protandim® Nrf2 Synergizer™* (US)35 (Synergy Effect)

The beautiful thing about the synergy of Protandim Nrf2 Synergizer is that the same ingredients act differently together than they do individually. This means very small amounts of each herb are needed to provide an effective dose.*

What are the benefits of activating Nrf2?

Protandim Nrf2 Synergizer supports overall health and can help you age well by helping cells protect, repair, and rejuvenate themselves naturally. In addition to the benefits listed above, published research on Protandim Nrf2 Synergizer has shown benefits for maintaining cardiovascular, brain, nervous system, joint, and muscle health.*

The effects of oxidative stress are widespread throughout the body. And the science of nutrigenomics and activating Nrf2 continues to grow. So, while it’s unclear if supplementation has any direct effect, Nrf2 has been found to be related to the following:*

  • DNA and cell health
  • Normal aging
  • Immune health
  • Cardiovascular health
  • Brain health
  • Skin health
  • Digestive health
  • Bone and joint health
  • Liver, pancreatic, kidney health
  • Oral health
  • Healthy hair growth

We recommend you talk to your doctor before taking any LifeVantage supplement.

Protandim Nrf2 Synergizer was the first, and it remains the most effective activator of Nrf2 available today. It can help your body perform at its full potential, so you stay healthy for as long as possible. *

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.